The Risk of High CNI Exposure

Reduce CNI-related Toxicities in post-transplant patients with Certican®

Hypertension

- CNIs raise BP via tubular salt reabsorption, renal and systemic vasoconstriction, and the sympathetic nervous system ^1,2

Dyslipidemia

- CNIs can increase cholesterol biosynthesis and reduce triglyceride breakdown¹

New-onset diabetes after transplantation (NODAT)

- CNIs interfere with signaling pancreatic B-cells leading to decrease in insulin secretion ¹

Dose Matters

The Higher the CNI Exposure, the Greater the Risk

Hence, guidelines and systematic reviews recommend to limit CNI exposure to avoid CNI-related toxicities^6-8

LOWER CNI EXPOSURE WITH

By enabling up to a 60% reduction in CNI exposure⁹ and offering anti-inflammatory, antiproliferative, and antiviral benefits, ¹⁰ Certican® helps reduce the risk of long-term CNI-related toxicities. ¹¹

Stay tuned for our next email, where we dive into the TRANSFORM study—highlighting how Certican^® with reduced CNI dose preserved graft function while minimizing CNI exposure.¹¹

Reduce CNI-related toxicities in post-transplant patients with Certican®

Abbreviations:
CNI, Calcineurin inhibitors; NODAT, New-onset diabetes after transplantation; BP, blood pressure; GFR, glomerular filtration rate; CsA, Cyclosporin; KDIGO, Kidney Disease: Improving Global Outcomest

References:
1. Farouk SS, et al.Adv Chronic Kidney Dis. 2020;27(1):56-66. 2. Noble J, et al.Best Pract Res Clin Gastroenterol . 2021;54-55:101762. 3. Ruggenenti P, et al. Kidney Int. 1993;43(3):706-711. 4. Robert N, et al. Cochrane Database Syst Rev. 2010;(1):CD007893. 5. Veroux M, et al. Clin Dev Immunol. 2013;2013:496974. 6. Rovin BH, et al.Kidney Int. 2021;100(4):753-779. 7. Sawinski D, et al. Am J Transplant. 2016;16(7):2117-2138. 8. Farkas SA, et al.Transpl Int. 2009;22(1):49-60. 9. Cibrik D, et al. Transplantation. 2013;95(7):933–942. 10.Pascual J, et al. J Am Soc Nephrol. 2018;29(7):1979-1991. 11. Mao B, et al. Molecules. 2022;27(16):5295.

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