Provide optimal
IS therapy to these high-risk transplant patients with Certican®
- 19.1% tBPAR incidence in patients EVR + rCNI
- Fewer tBPAR events occurred with increasing EVR levels (p<0.0001)
High probability of renal dysfunction (low & reduced eGFR) was found:
At low EVR concentrations
At high CNI levels
Increased dose of Certican® + rCNI is an optimal regimen to preserve renal function in KT patients.1
22.9%
in 1.5 EVR +
rCNI group
vs.
55.2%
in MPA +
Standard CNI group
High probability of renal dysfunction (low & reduced eGFR) was found:
57% reduction for any cancers; 95% CI 0.18, 1.02
Certican® with rCN was associated with lower risk of cancer compared with standard dose CNI therapy.1
Certican® with rCNI is a suitable alternative to the standard‐of‐care regimen with an advantage to reduce viral infections.3
Incidence of tBPAR, graft loss or death at 12 months (6.7% vs. 9.7%; p<0.001 for noninferiority)4
Lower eGFR decline at 12 months post LT compared to standard CNI therapy4
Certican® facilitates early tacrolimus minimization with comparable efficacy and superior renal function vs. standard CNI in LT patients.4
Comparable incidence of tBPAR, graft loss or death with standard CNI (p=0.334)5
No or Low hepatocellular carcinoma recurrence vs. standard CNI at 1-2 year post-LT6,7
Certican®with rCNI had sustained graft function with low risk of HCC recurrence.5-7
Abbreviations:
IS, immunosuppressant; LT, liver transplant; CNI, Calcineurin inhibitors; tBPAR, treated biopsy-proven acute rejection; eGFR, estimated glomerular filtration rate; rCNI, reduced-exposure calcineurin inhibitor; HCC, hepatocellular carcinoma
References:
1. Shihab FS, et al. Clin Transplant .2013: 27: 217–226. 2. Lim WH, et al. Kidney Int. 2017;91(4):954-963. 3. Berger SP, et al. Am J Transplant. 2019;19(11):3018-3034. 4. De Simone P, et al. Am J Transplant. 2012;12(11):3008-3020. 5. Fischer L, et al. Transplantation. 2015;99(7):1455-1462; 6. Jeng LB, et al. Am J Transplant. 2018;18(6):1435-1446. 7. Lee et al. Transplantation. 2021;105(7):1564-1575.
20 Pasir Panjang Road #10-25/28 Mapletree Business City (West Tower) Singapore 117439
Phone: +65 6722 6010
FOR HEALTHCARE PROFESSIONALS ONLY
APPROVAL CODE
