Hypertension management from the start:
Simplify therapy to support adherence and better BP control
1 in 3
newly diagnosed HTN patients fail to adhere to medications after the 1st year1,2
47-71%
of new HTN patients
stop their meds after 3 years3
Initial dual therapy
Patients need multiple drug classes, which together lower BP better than high-dose monotherapy.
SPCs are preferred
SPCs improve treatment persistence and are associated with lower all-cause mortality.
Adherence improved
more than two times
after 12 months
(OR 2.13, 95% CI: 1.3-3.47)*6
Better SBP reduction
Mean difference
-1.5 mmHg*7
Lower multiple CV risks (IRR 0.54-0.77)*8
Footnote
*Compared to equivalent free-dose (multiple pill) combination.
Abbreviations:
ACE, angiotensin-converting enzyme; ARBs, Angiotensin Receptor Blockers; BP, blood pressure; CCB, Calcium Channel Blockers; CVD, cardiovascular diseases; HTN, hypertension; SPC, single-pill combination; VAL/AMLO, valsartan/amlodipine.
1. Sagara K, et al. J Hypertens. 2024;42(4):718-726. 2. Wong MC, et al. Int J Cardiol. 2015;182:503-508. 3. Bourgault C, et al. J Hum Hypertens. 2005;19(8):607-613. 4. McEvoy JW, et al. Eur Heart J. 2024;45(38):3912-4018. 5. Mancia G, et al. J Hypertens. 2023;41(12):1874-2071. 6. Weisser B, et al. High Blood Press Cardiovasc Prev. 2020;27(2):157-164. 7. Kengne AP, et al. Expert Rev Pharmacoecon Outcomes Res. 2024;24(7):817-827. 8. Weisser B, et al. Eur Heart J Cardiovasc Pharmacother. 2025;10(8):686-693. 9. Smith TR et al. J Clin Hypertens 2007;9:355-364. 10. Poldermans D et al. Clin Ther 2007;29:279-289. 11. Giles TD et al. Blood Press Monit 2011;16:87-95. 12. Schmieder RE, et al. Hypertension. 2023;80(5):1127-1135. 13. Tung YC et al. J Clin Hypertens. 2015;17(1):51-58.
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