Enhancing Adherence and Outcomes in Hypertension Care
Guideline-Based
Practice with SPC solutions from Novartis
Improved adherence
Hypertensive patients on SPCs are twice as likely to adhere to therapy (OR 0.42, p<0.01)1
Better BP reduction
Compared with FEC, patients on SPC had BP significantly reduced at week 122
Single Pill
Decreased cardiovascular events, all-cause morality, hospitalizations, and costs
Evidence-based practice
SPCs improve adherence, persistence, and are associated with better outcomes.
Simplicity is key
For HTN patients, therapy should be simplified and a SPC is recommended at any step.
Abbreviations:
ARBs, Angiotensin II Receptor Blockers; BP, blood pressure; CCBs, Calcium Channel Blockers; CI, confident interval; IRR, incidence rate ratios; HTN, hypertension; HR, hazard ratio; MACE, major adverse cardiovascular event; MPC, multi-pill combination; SPC, single-pill combination; FEC, free-equivalent combination; VAL/AMLO, valsartan/amlodipine; VAL/AMLO/HCTZ, valsartan/amlodipine/hydrochlorothiazide.
References:
1. Kengne AP, et al. Expert Rev Pharmacoecon Outcomes Res. 2024;24(7):817-827.; 2. Parati G, et al. Hypertension. 2021;77(2):692-705.; 3. Weisser B et al. Eur Heart J Cardiovasc Pharmacother. 2025;10(8):686-693.; 4. McEvoy JW, et al. Eur Heart J. 2024;45(38):3912-4018.; 5. Mancia G, et al. J Hypertens. 2023;41(12):1874-2071.; 6. Unger T, et al. Hypertension. 2020;75(6):1334-1357.; 7. Schmieder RE, et al. Hypertension. 2023;80(5):1127-1135.; 8. Tung YC et al. J Clin Hypertens. 2015;17(1):51–58.
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